2 types
- nicotinic ( ionotropic , fast) - blocked by tubocurarine
activated by nicotine, NMJ, skeletal muscles
- muscarinic ( metabotropic, slow) - blocked by atropine
heart (decrease heart rate) , GI muscle (contract), blood vessels(indirect, vasodilation), constrict pupil, hypotension
>>>>Removal
- cholinesterase (enzyme)
highly concentrated at NMJ... why? for ACh to function, ACh must be removed immediately
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